2.1. Apparatus

基本信息

• 标准
  欧洲药典
• 版本
  EP8.0
• 来源
  VOLUME 1
• 分类
  GENERAL CHAPTERS
• 页码
  15

EUROPEAN PHARMACOPOEIA 8.02.1.3. Ultraviolet ray lamps for analytical purposes 2.1. APPARATUS 01/2008:20101 2.1.1. DROPPERS The term ‘drops’ means standard drops delivered from a standard dropper as described below. Standard droppers (Figure 2.1.1-1) are constructed of practically colourless glass. The lower extremity has a circular orifice in a flat surface at right angles to the axis. Figure 2.1.1.-1. –Standard dropper Dimensions in millimetres Other droppers may be used provided they comply with the following test. 20 drops ofwater Rat 20 ± 1 °C flowing freely from the dropper held in the vertical position at a constant rate of 1 drop per second weighs 1000 ± 50 mg. The dropper must be carefully cleaned before use. Carry out 3 determinations on any given dropper. No result may deviate by more than 5 per cent from the mean of the 3 determinations. 01/2008:20102 2.1.2. COMPARATIVE TABLE OF POROSITY OF SINTERED-GLASS FILTERS (1) Table 2.1.2.-1 Porosity number (Ph. Eur.) (2) Maximum diameter of pores in micrometres Germany France United Kingdom 1.6 less than 1.65f –– – 1-2.5 5 – 5 4 1.6 - 4 ––– – 4-6 – 5 – 104 - 10 4f – 4 1610 - 16 44 – 4016 - 40333 – 40 - 50 –– 2 10040 - 10022 – – 100 - 120 –– 1 160100 - 16011 – – 150 - 20000 – 250160 - 250 ––– – 200 - 500 – 00 – Special Uses Diameters in micrometres <2.5 Bacteriological filtration 4-10 Ultra-fine filtration, separation of micro-organisms of large diameter 10 - 40 Analytical filtration, very fine filtration of mercury, very fine dispersion of gases 40 - 100 Fine filtration, filtration of mercury, fine dispersion of gases 100 - 160 Filtration of coarse materials, dispersion and washing of gases, support for other filter materials 160 - 500 Filtration of very coarse materials, dispersion and washing of gases. 01/2008:20103 2.1.3. ULTRAVIOLET RAY LAMPS FOR ANALYTICAL PURPOSES Mercury vapour in quartz lamps is used as the source of ultraviolet light. A suitable filter may be fitted to eliminate the visible part of the spectrum emitted by the lamp. When the Pharmacopoeia prescribes in a test the use of ultraviolet light of wavelength 254 nm or 365 nm, an instrument consisting of a mercury vapour lamp and a filter which gives an emission band with maximum intensity at about 254 nm or 365 nm is used. The lamp used should be capable of revealing without doubt a standard spot of sodium salicylate with a diameter of about 5 mm on a support ofsilica gel G R,thespotbeing examined while in a position normal to the radiation. For this purpose apply 5 μL of a 0.4 g/L solution ofsodium salicylate Rinalcohol R (3) for lamps of maximum output at 254nmand5μLofa2g/Lsolutioninalcohol R (3) for lamps of maximumoutputat365nm.Thedistancebetweenthelamp and the chromatographic plate under examination used in a pharmacopoeial test should never exceed the distance used to carry out the above test. (1) The given limits are only approximate. (2) The European Pharmacopoeia has adopted the system proposed by the International Organization for Standardization (ISO). (3) Thealcohol Rused must be free from fluorescence. General Notices (1) apply to all monographs and other texts15

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